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Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis
المؤلفون المشاركون
Qin, Yuan-Han
Zhao, Yan-Jun
Zhou, Tian-Biao
Huang, Wei-Fang
Lei, Feng-Ying
Su, Li-Na
المصدر
International Journal of Nephrology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and MCNS susceptibility.
Method.
A predefined literature search and selection of eligible relevant studies were performed to collect the data from electronic databases.
Results.
Six articles were identified for the analysis of association between ACE I/D gene polymorphism and MCNS risk, including 4 for Asians, one in Caucasian population and one for Africans.
There was a markedly positive association between D allele or DD genotype and MCNS susceptibility in Asians (D: P=.01, DD: P=.02), but not for Caucasians and Africans (Caucasians: D: P=.16, DD: P=.98; Africans: D: P=.81, DD: P=.49).
Furthermore, the II genotype seemed not to play a protective role against MCNS risk for Asians, Caucasians and Africans (P=.12, P=.09, P=.76, resp.).
Interestingly, there was also significant association between ACE I/D gene polymorphism and MCNS susceptibility in overall populations (D: P=.007, DD: P=.04, II: P=.03).
Conclusion.
D allele or DD genotype might be a significant genetic molecular marker for MCNS susceptibility in Asians and overall populations, but not for Caucasians and Africans.
More larger and rigorous genetic epidemiological investigations are required to further explore this association.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Tian-Biao& Qin, Yuan-Han& Su, Li-Na& Lei, Feng-Ying& Huang, Wei-Fang& Zhao, Yan-Jun. 2011. Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465796
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Tian-Biao…[et al.]. Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-465796
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Tian-Biao& Qin, Yuan-Han& Su, Li-Na& Lei, Feng-Ying& Huang, Wei-Fang& Zhao, Yan-Jun. Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465796
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465796
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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