Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis
Joint Authors
Qin, Yuan-Han
Zhao, Yan-Jun
Zhou, Tian-Biao
Huang, Wei-Fang
Lei, Feng-Ying
Su, Li-Na
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and MCNS susceptibility.
Method.
A predefined literature search and selection of eligible relevant studies were performed to collect the data from electronic databases.
Results.
Six articles were identified for the analysis of association between ACE I/D gene polymorphism and MCNS risk, including 4 for Asians, one in Caucasian population and one for Africans.
There was a markedly positive association between D allele or DD genotype and MCNS susceptibility in Asians (D: P=.01, DD: P=.02), but not for Caucasians and Africans (Caucasians: D: P=.16, DD: P=.98; Africans: D: P=.81, DD: P=.49).
Furthermore, the II genotype seemed not to play a protective role against MCNS risk for Asians, Caucasians and Africans (P=.12, P=.09, P=.76, resp.).
Interestingly, there was also significant association between ACE I/D gene polymorphism and MCNS susceptibility in overall populations (D: P=.007, DD: P=.04, II: P=.03).
Conclusion.
D allele or DD genotype might be a significant genetic molecular marker for MCNS susceptibility in Asians and overall populations, but not for Caucasians and Africans.
More larger and rigorous genetic epidemiological investigations are required to further explore this association.
American Psychological Association (APA)
Zhou, Tian-Biao& Qin, Yuan-Han& Su, Li-Na& Lei, Feng-Ying& Huang, Wei-Fang& Zhao, Yan-Jun. 2011. Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465796
Modern Language Association (MLA)
Zhou, Tian-Biao…[et al.]. Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-465796
American Medical Association (AMA)
Zhou, Tian-Biao& Qin, Yuan-Han& Su, Li-Na& Lei, Feng-Ying& Huang, Wei-Fang& Zhao, Yan-Jun. Relationship between Angiotensin-Converting Enzyme InsertionDeletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome : A Meta-Analysis. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465796