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Differential Gene Expression in High- and Low-Active Inbred Mice
المؤلفون المشاركون
Kochan, Kelli J.
Riggs, Penny K.
Ceaser, Tyrone
Dawes, Michelle
Lightfoot, J. Timothy
Hamilton, Alicia T.
Moore-Harrison, Trudy
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Numerous candidate genes have been suggested in the recent literature with proposed roles in regulation of voluntary physical activity, with little evidence of these genes’ functional roles.
This study compared the haplotype structure and expression profile in skeletal muscle and brain of inherently high- (C57L/J) and low- (C3H/HeJ) active mice.
Expression of nine candidate genes [Actn2, Actn3, Casq1, Drd2, Lepr, Mc4r, Mstn, Papss2, and Glut4 (a.k.a.
Slc2a4)] was evaluated via RT-qPCR.
SNPs were observed in regions of Actn2, Casq1, Drd2, Lepr, and Papss2; however, no SNPs were located in coding sequences or associated with any known regulatory sequences.
In mice exposed to a running wheel, Casq1 (P=0.0003) and Mstn (P=0.002) transcript levels in the soleus were higher in the low-active mice.
However, when these genes were evaluated in naïve animals, differential expression was not observed, demonstrating a training effect.
Among naïve mice, no genes in either tissue exhibited differential expression between strains.
Considering that no obvious SNP mechanisms were determined or differential expression was observed, our results indicate that genomic structural variation or gene expression data alone is not adequate to establish any of these genes’ candidacy or causality in relation to regulation of physical activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dawes, Michelle& Moore-Harrison, Trudy& Hamilton, Alicia T.& Ceaser, Tyrone& Kochan, Kelli J.& Riggs, Penny K.…[et al.]. 2014. Differential Gene Expression in High- and Low-Active Inbred Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-465854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dawes, Michelle…[et al.]. Differential Gene Expression in High- and Low-Active Inbred Mice. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-465854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dawes, Michelle& Moore-Harrison, Trudy& Hamilton, Alicia T.& Ceaser, Tyrone& Kochan, Kelli J.& Riggs, Penny K.…[et al.]. Differential Gene Expression in High- and Low-Active Inbred Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-465854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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