Functional Epigenetic Analysis of Prostate Carcinoma : A Role for Seryl-tRNA Synthetase?
المؤلفون المشاركون
Ikromov, Odiljon
Krause, Hans
Magheli, Ahmed
Alkamal, Imad
Ratert, Nadine
Miller, Kurt
Kempkensteffen, Carsten
Sendeski, Mauricio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Transcriptional silencing, as a result of aberrant promoter hypermethylation, is a common mechanism through which genes in cancer cells become inactive.
Functional epigenetic screens using demethylating agents to reexpress transcriptional silenced genes may identify such inactivated genes for needing further evaluation.
We aimed to identify genes so far not known to be inactivated by promoter hypermethylation in prostate cancer.
DU-145 and LNCaP cells were treated with the DNMT inhibitor zebularine.
Expression changes of total RNA from treated and untreated cells were compared using an RNA expression microarray.
Genes upregulated more than 2-fold were evaluated by RT-qPCR in 50 cases of paired normal and tumor tissues of prostate cancer patients.
SARS was found to be downregulated in prostate cancer in 42/50 cases (84%).
In addition, GADD45A and SPRY4 showed a remarkable diminished expression (88% and 74%, resp.).
The gold standard for promoter hypermethylation-inactivated genes in prostate cancer (GSTP1) was repressed in 90% of our patient samples.
ROC analyses reported statistically significant AUC curves in SARS, GADD45A, and GSTP1 and positive Spearman correlations were found between these genes.
SARS was discovered to be a novel gene that is repressed in prostate cancer and could therefore be recommended for its involvement in prostate carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ikromov, Odiljon& Alkamal, Imad& Magheli, Ahmed& Ratert, Nadine& Sendeski, Mauricio& Miller, Kurt…[et al.]. 2014. Functional Epigenetic Analysis of Prostate Carcinoma : A Role for Seryl-tRNA Synthetase?. Journal of Biomarkers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-465969
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ikromov, Odiljon…[et al.]. Functional Epigenetic Analysis of Prostate Carcinoma : A Role for Seryl-tRNA Synthetase?. Journal of Biomarkers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-465969
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ikromov, Odiljon& Alkamal, Imad& Magheli, Ahmed& Ratert, Nadine& Sendeski, Mauricio& Miller, Kurt…[et al.]. Functional Epigenetic Analysis of Prostate Carcinoma : A Role for Seryl-tRNA Synthetase?. Journal of Biomarkers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-465969
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465969
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر