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Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release
المؤلفون المشاركون
Ghosh, Amitava
Roy, Sarbani
Roy, Amitava
Ali, Kazi Asraf
Deb, Jyotirmoy
Roy, Kalpana
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
علم الصيدلة
الملخص EN
The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique.
In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were X60, X120, T50, T90, n, and b values obtained from dissolution kinetics data.
The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism.
The drug release was found to reveal zero order kinetics.
The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels.
There were no significant drug-polymer interactions as revealed by infrared spectra.
It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roy, Amitava& Roy, Kalpana& Roy, Sarbani& Deb, Jyotirmoy& Ghosh, Amitava& Ali, Kazi Asraf. 2012. Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466134
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roy, Amitava…[et al.]. Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release. ISRN Pharmaceutics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-466134
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roy, Amitava& Roy, Kalpana& Roy, Sarbani& Deb, Jyotirmoy& Ghosh, Amitava& Ali, Kazi Asraf. Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466134
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466134
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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