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Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release
Joint Authors
Ghosh, Amitava
Roy, Sarbani
Roy, Amitava
Ali, Kazi Asraf
Deb, Jyotirmoy
Roy, Kalpana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique.
In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were X60, X120, T50, T90, n, and b values obtained from dissolution kinetics data.
The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism.
The drug release was found to reveal zero order kinetics.
The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels.
There were no significant drug-polymer interactions as revealed by infrared spectra.
It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.
American Psychological Association (APA)
Roy, Amitava& Roy, Kalpana& Roy, Sarbani& Deb, Jyotirmoy& Ghosh, Amitava& Ali, Kazi Asraf. 2012. Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466134
Modern Language Association (MLA)
Roy, Amitava…[et al.]. Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release. ISRN Pharmaceutics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-466134
American Medical Association (AMA)
Roy, Amitava& Roy, Kalpana& Roy, Sarbani& Deb, Jyotirmoy& Ghosh, Amitava& Ali, Kazi Asraf. Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets : Influence of Some Hydrophillic Polymers on the Release. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466134