Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers
المؤلفون المشاركون
Clapp, Brian
Donald, Ann
Hunt, Joanne
Tilling, Lindsey
Chowienczyk, Phil
المصدر
Cardiology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Previous studies suggest a protracted course of recovery after mechanical endothelial injury; confounders may include degree of injury and concomitant endothelial dysfunction.
We sought to define the time course of endothelial function recovery using flow-mediated dilation (FMD), after ischaemia-reperfusion (IR) and mechanical injury in patients and healthy volunteers.
The contribution of circulating CD133+/CD34+/VEGFR2+ “endothelial progenitor” (EPC) or repair cells to endothelial repair was also examined.
Methods.
28 healthy volunteers aged 18–35 years underwent transient forearm ischaemia induced by cuff inflation around the proximal biceps and radial artery mechanical injury induced by inserting a wire through a cannula.
A more severe mechanical injury was induced using an arterial sheath and catheter inserted into the radial artery of 18 patients undergoing angiography.
Results.
IR and mechanical injury produced immediate impairment of FMD (from 6.5 ± 1.2% to 2.9 ± 2.2% and from 7.4 ± 2.3% to 1.5 ± 1.6% for IR and injury, resp., each P<0.001) but recovered within 6 hours and 2 days, respectively.
FMD took up to 4 months to recover in patients.
Circulating EPC did not change significantly during the injury/recovery period in all subjects.
Conclusions.
Recovery of endothelial function after IR and mechanical injury is rapid and not associated with a change in circulating EPC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tilling, Lindsey& Hunt, Joanne& Donald, Ann& Clapp, Brian& Chowienczyk, Phil. 2014. Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers. Cardiology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tilling, Lindsey…[et al.]. Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers. Cardiology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-466369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tilling, Lindsey& Hunt, Joanne& Donald, Ann& Clapp, Brian& Chowienczyk, Phil. Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers. Cardiology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر