Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers
Joint Authors
Clapp, Brian
Donald, Ann
Hunt, Joanne
Tilling, Lindsey
Chowienczyk, Phil
Source
Cardiology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Previous studies suggest a protracted course of recovery after mechanical endothelial injury; confounders may include degree of injury and concomitant endothelial dysfunction.
We sought to define the time course of endothelial function recovery using flow-mediated dilation (FMD), after ischaemia-reperfusion (IR) and mechanical injury in patients and healthy volunteers.
The contribution of circulating CD133+/CD34+/VEGFR2+ “endothelial progenitor” (EPC) or repair cells to endothelial repair was also examined.
Methods.
28 healthy volunteers aged 18–35 years underwent transient forearm ischaemia induced by cuff inflation around the proximal biceps and radial artery mechanical injury induced by inserting a wire through a cannula.
A more severe mechanical injury was induced using an arterial sheath and catheter inserted into the radial artery of 18 patients undergoing angiography.
Results.
IR and mechanical injury produced immediate impairment of FMD (from 6.5 ± 1.2% to 2.9 ± 2.2% and from 7.4 ± 2.3% to 1.5 ± 1.6% for IR and injury, resp., each P<0.001) but recovered within 6 hours and 2 days, respectively.
FMD took up to 4 months to recover in patients.
Circulating EPC did not change significantly during the injury/recovery period in all subjects.
Conclusions.
Recovery of endothelial function after IR and mechanical injury is rapid and not associated with a change in circulating EPC.
American Psychological Association (APA)
Tilling, Lindsey& Hunt, Joanne& Donald, Ann& Clapp, Brian& Chowienczyk, Phil. 2014. Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers. Cardiology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466369
Modern Language Association (MLA)
Tilling, Lindsey…[et al.]. Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers. Cardiology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-466369
American Medical Association (AMA)
Tilling, Lindsey& Hunt, Joanne& Donald, Ann& Clapp, Brian& Chowienczyk, Phil. Arterial Injury and Endothelial Repair : Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers. Cardiology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466369