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Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome
المؤلفون المشاركون
Zhang, Yuan
Feiyang, Diao
Liu, Jia-Yin
Gao, Chao
Cui, Yu-Gui
Xue, Dai
Gao, Li
Li, Mei
Ma, Xiang
Xiaonan, Dai
Lingling, Gao
Boqun, Xu
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
We previously found that expression of SET gene was up-regulated in polycystic ovaries by using microarray.
It suggested that SET may be an attractive candidate regulator involved in the pathophysiology of polycystic ovary syndrome (PCOS).
In this study, expression and cellular localization of SET protein were investigated in human polycystic and normal ovaries.
Method.
Ovarian tissues, six normal ovaries and six polycystic ovaries, were collected during transsexual operation and surgical treatment with the signed consent form.
The cellular localization of SET protein was observed by immunohistochemistry.
The expression levels of SET protein were analyzed by Western Blot.
Result.
SET protein was expressed predominantly in the theca cells and oocytes of human ovarian follicles in both PCOS ovarian tissues and normal ovarian tissues.
The level of SET protein expression in polycystic ovaries was triple higher than that in normal ovaries (P<0.05).
Conclusion.
SET was overexpressed in polycystic ovaries more than that in normal ovaries.
Combined with its localization in theca cells, SET may participate in regulating ovarian androgen biosynthesis and the pathophysiology of hyperandrogenism in PCOS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Boqun, Xu& Xiaonan, Dai& Cui, Yu-Gui& Lingling, Gao& Xue, Dai& Gao, Chao…[et al.]. 2013. Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466406
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Boqun, Xu…[et al.]. Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466406
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Boqun, Xu& Xiaonan, Dai& Cui, Yu-Gui& Lingling, Gao& Xue, Dai& Gao, Chao…[et al.]. Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466406
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466406
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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