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Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome
Joint Authors
Zhang, Yuan
Feiyang, Diao
Liu, Jia-Yin
Gao, Chao
Cui, Yu-Gui
Xue, Dai
Gao, Li
Li, Mei
Ma, Xiang
Xiaonan, Dai
Lingling, Gao
Boqun, Xu
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
We previously found that expression of SET gene was up-regulated in polycystic ovaries by using microarray.
It suggested that SET may be an attractive candidate regulator involved in the pathophysiology of polycystic ovary syndrome (PCOS).
In this study, expression and cellular localization of SET protein were investigated in human polycystic and normal ovaries.
Method.
Ovarian tissues, six normal ovaries and six polycystic ovaries, were collected during transsexual operation and surgical treatment with the signed consent form.
The cellular localization of SET protein was observed by immunohistochemistry.
The expression levels of SET protein were analyzed by Western Blot.
Result.
SET protein was expressed predominantly in the theca cells and oocytes of human ovarian follicles in both PCOS ovarian tissues and normal ovarian tissues.
The level of SET protein expression in polycystic ovaries was triple higher than that in normal ovaries (P<0.05).
Conclusion.
SET was overexpressed in polycystic ovaries more than that in normal ovaries.
Combined with its localization in theca cells, SET may participate in regulating ovarian androgen biosynthesis and the pathophysiology of hyperandrogenism in PCOS.
American Psychological Association (APA)
Boqun, Xu& Xiaonan, Dai& Cui, Yu-Gui& Lingling, Gao& Xue, Dai& Gao, Chao…[et al.]. 2013. Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466406
Modern Language Association (MLA)
Boqun, Xu…[et al.]. Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466406
American Medical Association (AMA)
Boqun, Xu& Xiaonan, Dai& Cui, Yu-Gui& Lingling, Gao& Xue, Dai& Gao, Chao…[et al.]. Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466406