![](/images/graphics-bg.png)
Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms
المؤلفون المشاركون
Bernardes, Miguel
Monteiro, Joaquim
Sousa, Hugo
Lima, Aurea
Medeiros, Rui
Seabra, Vitor
Azevedo, Rita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Methotrexate (MTX), the most used drug in rheumatoid arthritis (RA) treatment, showing variability in clinical response, is often associated with genetic polymorphisms.
This study aimed to elucidate the role of methylenetetrahydrofolate reductase (MTHFR) C677T and aminoimidazole carboxamide adenosine ribonucleotide transformylase (ATIC) T675C polymorphisms and clinicopathological variables in clinical response to MTX in Portuguese RA patients.
Methods.
Study included 233 RA patients treated with MTX for at least six months.
MTHFR C677T and ATIC T675C polymorphisms were genotyped and clinicopathological variables were collected.
Statistical analyses were performed and binary logistic regression method adjusted to possible confounding variables.
Results.
Multivariate analyses demonstrated that MTHFR 677TT (OR = 4.63; P=0.013) and ATIC 675T carriers (OR = 5.16; P=0.013) were associated with over 4-fold increased risk for nonresponse.
For clinicopathological variables, noncurrent smokers (OR = 7.98; P=0.001), patients positive to anti-cyclic citrullinated peptide (OR = 3.53; P=0.004) and antinuclear antibodies (OR = 2.28; P=0.045), with higher health assessment questionnaire score (OR = 2.42; P=0.007), and nonsteroidal anti-inflammatory drug users (OR = 2.77; P=0.018) were also associated with nonresponse.
Contrarily, subcutaneous administration route (OR = 0.11; P<0.001) was associated with response.
Conclusion.
Our study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lima, Aurea& Monteiro, Joaquim& Bernardes, Miguel& Sousa, Hugo& Azevedo, Rita& Seabra, Vitor…[et al.]. 2014. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-466488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lima, Aurea…[et al.]. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-466488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lima, Aurea& Monteiro, Joaquim& Bernardes, Miguel& Sousa, Hugo& Azevedo, Rita& Seabra, Vitor…[et al.]. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-466488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)