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Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms
Joint Authors
Bernardes, Miguel
Monteiro, Joaquim
Sousa, Hugo
Lima, Aurea
Medeiros, Rui
Seabra, Vitor
Azevedo, Rita
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Methotrexate (MTX), the most used drug in rheumatoid arthritis (RA) treatment, showing variability in clinical response, is often associated with genetic polymorphisms.
This study aimed to elucidate the role of methylenetetrahydrofolate reductase (MTHFR) C677T and aminoimidazole carboxamide adenosine ribonucleotide transformylase (ATIC) T675C polymorphisms and clinicopathological variables in clinical response to MTX in Portuguese RA patients.
Methods.
Study included 233 RA patients treated with MTX for at least six months.
MTHFR C677T and ATIC T675C polymorphisms were genotyped and clinicopathological variables were collected.
Statistical analyses were performed and binary logistic regression method adjusted to possible confounding variables.
Results.
Multivariate analyses demonstrated that MTHFR 677TT (OR = 4.63; P=0.013) and ATIC 675T carriers (OR = 5.16; P=0.013) were associated with over 4-fold increased risk for nonresponse.
For clinicopathological variables, noncurrent smokers (OR = 7.98; P=0.001), patients positive to anti-cyclic citrullinated peptide (OR = 3.53; P=0.004) and antinuclear antibodies (OR = 2.28; P=0.045), with higher health assessment questionnaire score (OR = 2.42; P=0.007), and nonsteroidal anti-inflammatory drug users (OR = 2.77; P=0.018) were also associated with nonresponse.
Contrarily, subcutaneous administration route (OR = 0.11; P<0.001) was associated with response.
Conclusion.
Our study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment.
American Psychological Association (APA)
Lima, Aurea& Monteiro, Joaquim& Bernardes, Miguel& Sousa, Hugo& Azevedo, Rita& Seabra, Vitor…[et al.]. 2014. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-466488
Modern Language Association (MLA)
Lima, Aurea…[et al.]. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-466488
American Medical Association (AMA)
Lima, Aurea& Monteiro, Joaquim& Bernardes, Miguel& Sousa, Hugo& Azevedo, Rita& Seabra, Vitor…[et al.]. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients : Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-466488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466488