Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
المؤلفون المشاركون
Zhao, Jingru
Liu, Zongjie
Cui, Lili
Wang, Lina
Zhang, Xiaolin
Li, Yanhua
Qiao, Huimin
Xing, Yinxue
Zhu, Chunhua
Zhang, Xiangjian
Dong, Lipeng
Wang, Chaohui
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment.
Parthenolide (PN) has been proved to elicit a wide range of biological activities through its anti-inflammatory action in the treatment of migraine, arthritis, and atherosclerosis.
To decide whether this effect applies to ischemic injury in brain, we therefore investigate the potential neuroprotective role of PN and the underlying mechanisms.
Male Sprague-Dawley rats were randomly divided into Saline, Vehicle, and PN groups and a permanent middle cerebral artery occlusion (MCAO) model was used.
PN administered intraperitoneally immediately after cerebral ischemia and once daily on the following days.
At time points after MCAO, neurological deficit, infarct volume, and brain water content were measured.
Immunohistochemistry, western blot and RT-PCR were used to analyze the expression of NF-κB and caspase-1 in ischemic brain tissue.
Phospho-p38MAPK and claudin-5 were detected by western blot.
The results indicated that PN dramatically ameliorated neurological deficit, brain water content, and infarct volume, downregulated NF-κB, phospho-p38MAPK, and caspase-1 expressions, and upregulated claudin-5 expression in ischemic brain tissue.
Conclusions.
PN protected the brain from damage caused by MCAO; this effect may be through downregulating NF-κB, phosho-p38MAPK, and caspase-1 expressions and ameliorating BBB permeability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Lipeng& Qiao, Huimin& Zhang, Xiangjian& Zhang, Xiaolin& Wang, Chaohui& Wang, Lina…[et al.]. 2013. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-466694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Lipeng…[et al.]. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-466694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Lipeng& Qiao, Huimin& Zhang, Xiangjian& Zhang, Xiaolin& Wang, Chaohui& Wang, Lina…[et al.]. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-466694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر