Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
Joint Authors
Zhao, Jingru
Liu, Zongjie
Cui, Lili
Wang, Lina
Zhang, Xiaolin
Li, Yanhua
Qiao, Huimin
Xing, Yinxue
Zhu, Chunhua
Zhang, Xiangjian
Dong, Lipeng
Wang, Chaohui
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment.
Parthenolide (PN) has been proved to elicit a wide range of biological activities through its anti-inflammatory action in the treatment of migraine, arthritis, and atherosclerosis.
To decide whether this effect applies to ischemic injury in brain, we therefore investigate the potential neuroprotective role of PN and the underlying mechanisms.
Male Sprague-Dawley rats were randomly divided into Saline, Vehicle, and PN groups and a permanent middle cerebral artery occlusion (MCAO) model was used.
PN administered intraperitoneally immediately after cerebral ischemia and once daily on the following days.
At time points after MCAO, neurological deficit, infarct volume, and brain water content were measured.
Immunohistochemistry, western blot and RT-PCR were used to analyze the expression of NF-κB and caspase-1 in ischemic brain tissue.
Phospho-p38MAPK and claudin-5 were detected by western blot.
The results indicated that PN dramatically ameliorated neurological deficit, brain water content, and infarct volume, downregulated NF-κB, phospho-p38MAPK, and caspase-1 expressions, and upregulated claudin-5 expression in ischemic brain tissue.
Conclusions.
PN protected the brain from damage caused by MCAO; this effect may be through downregulating NF-κB, phosho-p38MAPK, and caspase-1 expressions and ameliorating BBB permeability.
American Psychological Association (APA)
Dong, Lipeng& Qiao, Huimin& Zhang, Xiangjian& Zhang, Xiaolin& Wang, Chaohui& Wang, Lina…[et al.]. 2013. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-466694
Modern Language Association (MLA)
Dong, Lipeng…[et al.]. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-466694
American Medical Association (AMA)
Dong, Lipeng& Qiao, Huimin& Zhang, Xiangjian& Zhang, Xiaolin& Wang, Chaohui& Wang, Lina…[et al.]. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model : Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-466694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466694