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Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens : Implications for the Evolution of a Genetic Code Expansion Cassette
المؤلفون المشاركون
O'Toole, Paul W.
Peyret, Pierre
Brugère, Jean-François
Gribaldo, Simonetta
Borrel, Guillaume
Gaci, Nadia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Pyrrolysine (Pyl), the 22nd proteogenic amino acid, was restricted until recently to few organisms.
Its translational use necessitates the presence of enzymes for synthesizing it from lysine, a dedicated amber stop codon suppressor tRNA, and a specific amino-acyl tRNA synthetase.
The three genomes of the recently proposed Thermoplasmata-related 7th order of methanogens contain the complete genetic set for Pyl synthesis and its translational use.
Here, we have analyzed the genomic features of the Pyl-coding system in these three genomes with those previously known from Bacteria and Archaea and analyzed the phylogeny of each component.
This shows unique peculiarities, notably an amber tRNAPyl with an imperfect anticodon stem and a shortened tRNAPyl synthetase.
Phylogenetic analysis indicates that a Pyl-coding system was present in the ancestor of the seventh order of methanogens and appears more closely related to Bacteria than to Methanosarcinaceae, suggesting the involvement of lateral gene transfer in the spreading of pyrrolysine between the two prokaryotic domains.
We propose that the Pyl-coding system likely emerged once in Archaea, in a hydrogenotrophic and methanol-H2-dependent methylotrophic methanogen.
The close relationship between methanogenesis and the Pyl system provides a possible example of expansion of a still evolving genetic code, shaped by metabolic requirements.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Borrel, Guillaume& Gaci, Nadia& Peyret, Pierre& O'Toole, Paul W.& Gribaldo, Simonetta& Brugère, Jean-François. 2014. Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens : Implications for the Evolution of a Genetic Code Expansion Cassette. Archaea،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-467002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Borrel, Guillaume…[et al.]. Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens : Implications for the Evolution of a Genetic Code Expansion Cassette. Archaea No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-467002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Borrel, Guillaume& Gaci, Nadia& Peyret, Pierre& O'Toole, Paul W.& Gribaldo, Simonetta& Brugère, Jean-François. Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens : Implications for the Evolution of a Genetic Code Expansion Cassette. Archaea. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-467002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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