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Modified High-Sucrose Diet-Induced Abdominally Obese and Normal-Weight Rats Developed High Plasma Free Fatty Acid and Insulin Resistance
المؤلفون المشاركون
Cao, Hongyi
Lv, Qingguo
Liu, Xuehui
Cao, Li
Tong, Nanwei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Introduction.
Metabolically obese but normal-weight (MONW) individuals have metabolic features of overt obesity, and abdominal adiposity is common in them.
Animal models of MONW individuals are lacking.
We aimed to develop an abdominally obese and normal-weight (AONW) rat model.
Methods and Results.
Young male Sprague-Dawley rats were fed chow or a modified high-sucrose (HS) diet for 20 weeks.
The HS diet induced increased visceral adipose tissue without increased body weight, reduced glucose disposal rates, and increased hepatic glucose output during the hyperinsulinemic-euglycemic clamp, increased plasma glucose during the intraperitoneal glucose tolerance test, and increased plasma free fatty acids.
Hepatic lipidosis and hepatocyte mitochondria swelling were found in HS rats through light microscopy and transmission electron microscopy; similar impairments were not observed in muscle.
RT-PCR showed that mRNA expression of uncoupling protein 3 and peroxisome proliferator-activated receptor-gamma coactivator 1α increased in muscle of HS rats, while expression of mitochondrial transcription factor A, glucose transporter type 4, and insulin receptor substrate-1 did not change significantly.
Conclusion.
AONW rats developed metabolic disorders seen in MONW individuals.
Steatosis, mitochondrial morphologic changes, and insulin resistance were more serious in liver than in muscle.
Genes involved in fatty acid metabolism and mitochondrial function changed in less impaired muscle.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Li& Liu, Xuehui& Cao, Hongyi& Lv, Qingguo& Tong, Nanwei. 2012. Modified High-Sucrose Diet-Induced Abdominally Obese and Normal-Weight Rats Developed High Plasma Free Fatty Acid and Insulin Resistance. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Li…[et al.]. Modified High-Sucrose Diet-Induced Abdominally Obese and Normal-Weight Rats Developed High Plasma Free Fatty Acid and Insulin Resistance. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-467025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Li& Liu, Xuehui& Cao, Hongyi& Lv, Qingguo& Tong, Nanwei. Modified High-Sucrose Diet-Induced Abdominally Obese and Normal-Weight Rats Developed High Plasma Free Fatty Acid and Insulin Resistance. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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