Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway
المؤلفون المشاركون
Ling, Wai Li
Biro, Adrienn
Arlaud, Gérard J.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Several studies suggest that the complement system is involved in atherogenesis.
To further investigate this question, we have studied the ability of native and modified forms of LDL to bind and activate C1, the complex protease that triggers the classical pathway of complement.
Unlike native LDL, oxidized (oxLDL) and enzymatically modified (E-LDL) derivatives were both recognized by the C1q subunit of C1, but only E-LDL particles, obtained by sequential treatment with a protease and then with cholesterol esterase, had the ability to trigger C1 activation.
Further investigations revealed that C1q recognizes a lipid component of E-LDL.
Several approaches, including reconstitution of model lipid vesicles, cosedimentation, and electron microscopy analyses, provided evidence that C1 binding to E-LDL particles is mediated by the C1q globular domain, which senses unesterified fatty acids generated by cholesterol esterase.
The potential implications of these findings in atherogenesis are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arlaud, Gérard J.& Biro, Adrienn& Ling, Wai Li. 2011. Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway. Journal of Lipids،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arlaud, Gérard J.…[et al.]. Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway. Journal of Lipids No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-467204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arlaud, Gérard J.& Biro, Adrienn& Ling, Wai Li. Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر