Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway
Joint Authors
Ling, Wai Li
Biro, Adrienn
Arlaud, Gérard J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Several studies suggest that the complement system is involved in atherogenesis.
To further investigate this question, we have studied the ability of native and modified forms of LDL to bind and activate C1, the complex protease that triggers the classical pathway of complement.
Unlike native LDL, oxidized (oxLDL) and enzymatically modified (E-LDL) derivatives were both recognized by the C1q subunit of C1, but only E-LDL particles, obtained by sequential treatment with a protease and then with cholesterol esterase, had the ability to trigger C1 activation.
Further investigations revealed that C1q recognizes a lipid component of E-LDL.
Several approaches, including reconstitution of model lipid vesicles, cosedimentation, and electron microscopy analyses, provided evidence that C1 binding to E-LDL particles is mediated by the C1q globular domain, which senses unesterified fatty acids generated by cholesterol esterase.
The potential implications of these findings in atherogenesis are discussed.
American Psychological Association (APA)
Arlaud, Gérard J.& Biro, Adrienn& Ling, Wai Li. 2011. Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway. Journal of Lipids،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467204
Modern Language Association (MLA)
Arlaud, Gérard J.…[et al.]. Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway. Journal of Lipids No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-467204
American Medical Association (AMA)
Arlaud, Gérard J.& Biro, Adrienn& Ling, Wai Li. Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467204