Endonuclease IV Is the Main Base Excision Repair Enzyme Involved in DNA Damage Induced by UVA Radiation and Stannous Chloride
المؤلفون المشاركون
De Mattos, José Carlos P.
Dantas, Flávio J. S.
Caldeira-de-Araújo, Adriano
Motta, Ellen S.
Souza-Santos, Paulo Thiago
Cassiano, Tuany R.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Stannous chloride (SnCl2) and UVA induce DNA lesions through ROS.
The aim of this work was to study the toxicity induced by UVA preillumination, followed by SnCl2 treatment.
E.
coli BER mutants were used to identify genes which could play a role in DNA lesion repair generated by these agents.
The survival assays showed (i) The nfo mutant was the most sensitive to SnCl2; (ii) lethal synergistic effect was observed after UVA pre-illumination, plus SnCl2 incubation, the nfo mutant being the most sensitive; (iii) wild type and nfo mutants, transformed with pBW21 plasmid (nfo+) had their survival increased following treatments.
The alkaline agarose gel electrophoresis assays pointed that (i) UVA induced DNA breaks and fpg mutant was the most sensitive; (ii) SnCl2-induced DNA strand breaks were higher than those from UVA and nfo mutant had the slowest repair kinetics; (iii) UVA+SnCl2 promoted an increase in DNA breaks than SnCl2 and, again, nfo mutant displayed the slowest repair kinetics.
In summary, Nfo protects E.
coli cells against damage induced by SnCl2 and UVA+ SnCl2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Motta, Ellen S.& Souza-Santos, Paulo Thiago& Cassiano, Tuany R.& Dantas, Flávio J. S.& Caldeira-de-Araújo, Adriano& De Mattos, José Carlos P.. 2010. Endonuclease IV Is the Main Base Excision Repair Enzyme Involved in DNA Damage Induced by UVA Radiation and Stannous Chloride. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-467218
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Motta, Ellen S.…[et al.]. Endonuclease IV Is the Main Base Excision Repair Enzyme Involved in DNA Damage Induced by UVA Radiation and Stannous Chloride. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-467218
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Motta, Ellen S.& Souza-Santos, Paulo Thiago& Cassiano, Tuany R.& Dantas, Flávio J. S.& Caldeira-de-Araújo, Adriano& De Mattos, José Carlos P.. Endonuclease IV Is the Main Base Excision Repair Enzyme Involved in DNA Damage Induced by UVA Radiation and Stannous Chloride. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-467218
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467218
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر