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A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway
المؤلفون المشاركون
Atkins, Gerald J.
Pandey, Akhilesh
Muthusamy, Babylakshmi
Lingala, Bhavya Teja
Raju, Rajesh
Mathur, Premendu Prakash
Radhakrishnan, Aneesha
Nanjappa, Vishalakshi
Singh, Kamlendra
Prasad, T. S. Keshava
Kuppusamy, Dheebika
Pan, Archana
Harsha, H. C.
Bhattacharjee, Mitali
Chatterjee, Aditi
المصدر
Journal of Signal Transduction
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
TNF-related weak inducer of apoptosis (TWEAK) is a new member of the TNF superfamily.
It signals through TNFRSF12A, commonly known as Fn14.
The TWEAK-Fn14 interaction regulates cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, tissue remodeling and inflammation.
Although TWEAK has been reported to be associated with autoimmune diseases, cancers, stroke, and kidney-related disorders, the downstream molecular events of TWEAK-Fn14 signaling are yet not available in any signaling pathway repository.
In this paper, we manually compiled from the literature, in particular those reported in human systems, the downstream reactions stimulated by TWEAK-Fn14 interactions.
Our manual amassment of the TWEAK-Fn14 pathway has resulted in cataloging of 46 proteins involved in various biochemical reactions and TWEAK-Fn14 induced expression of 28 genes.
We have enabled the availability of data in various standard exchange formats from NetPath, a repository for signaling pathways.
We believe that this composite molecular interaction pathway will enable identification of new signaling components in TWEAK signaling pathway.
This in turn may lead to the identification of potential therapeutic targets in TWEAK-associated disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhattacharjee, Mitali& Raju, Rajesh& Radhakrishnan, Aneesha& Nanjappa, Vishalakshi& Muthusamy, Babylakshmi& Singh, Kamlendra…[et al.]. 2012. A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467242
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhattacharjee, Mitali…[et al.]. A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467242
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhattacharjee, Mitali& Raju, Rajesh& Radhakrishnan, Aneesha& Nanjappa, Vishalakshi& Muthusamy, Babylakshmi& Singh, Kamlendra…[et al.]. A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467242
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467242
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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