A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway
Joint Authors
Atkins, Gerald J.
Pandey, Akhilesh
Muthusamy, Babylakshmi
Lingala, Bhavya Teja
Raju, Rajesh
Mathur, Premendu Prakash
Radhakrishnan, Aneesha
Nanjappa, Vishalakshi
Singh, Kamlendra
Prasad, T. S. Keshava
Kuppusamy, Dheebika
Pan, Archana
Harsha, H. C.
Bhattacharjee, Mitali
Chatterjee, Aditi
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
TNF-related weak inducer of apoptosis (TWEAK) is a new member of the TNF superfamily.
It signals through TNFRSF12A, commonly known as Fn14.
The TWEAK-Fn14 interaction regulates cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, tissue remodeling and inflammation.
Although TWEAK has been reported to be associated with autoimmune diseases, cancers, stroke, and kidney-related disorders, the downstream molecular events of TWEAK-Fn14 signaling are yet not available in any signaling pathway repository.
In this paper, we manually compiled from the literature, in particular those reported in human systems, the downstream reactions stimulated by TWEAK-Fn14 interactions.
Our manual amassment of the TWEAK-Fn14 pathway has resulted in cataloging of 46 proteins involved in various biochemical reactions and TWEAK-Fn14 induced expression of 28 genes.
We have enabled the availability of data in various standard exchange formats from NetPath, a repository for signaling pathways.
We believe that this composite molecular interaction pathway will enable identification of new signaling components in TWEAK signaling pathway.
This in turn may lead to the identification of potential therapeutic targets in TWEAK-associated disorders.
American Psychological Association (APA)
Bhattacharjee, Mitali& Raju, Rajesh& Radhakrishnan, Aneesha& Nanjappa, Vishalakshi& Muthusamy, Babylakshmi& Singh, Kamlendra…[et al.]. 2012. A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467242
Modern Language Association (MLA)
Bhattacharjee, Mitali…[et al.]. A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467242
American Medical Association (AMA)
Bhattacharjee, Mitali& Raju, Rajesh& Radhakrishnan, Aneesha& Nanjappa, Vishalakshi& Muthusamy, Babylakshmi& Singh, Kamlendra…[et al.]. A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467242