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Methylation-Associated Gene Silencing of RARB in Areca Carcinogens Induced Mouse Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Lai, Zi-Lun
Tsai, Ming-Hsui
Chang, Nai-Wen
Chen, Chuan-Mu
Fan, Shin-Ru
Cheng, Ju-Chien
Tsou, Yung-An
Chen, Hsiao-Ling
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-17
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures.
Therefore, we established an OSCC induced mouse model by 4-nitroquinoline-1-oxide (4-NQO), or arecoline, or both treatments, respectively.
These are the main two components of the areca nut that could increase the occurrence of OSCC.
We examined the effects with the noncommercial MCGI (mouse CpG islands) microarray for genome-wide screening the DNA methylation aberrant in induced OSCC mice.
The microarray results showed 34 hypermethylated genes in 4-NQO plus arecoline induced OSCC mice tongue tissues.
The examinations also used methylation-specific polymerase chain reaction (MS-PCR) and bisulfite sequencing to realize the methylation pattern in collected mouse tongue tissues and human OSCC cell lines of different grades, respectively.
These results showed that retinoic acid receptor β (RARB) was indicated in hypermethylation at the promoter region and the loss of expression during cancer development.
According to the results of real-time PCR, it was shown that de novo DNA methyltransferases were involved in gene epigenetic alternations of OSCC.
Collectively, our results showed that RARB hypermethylation was involved in the areca-associated oral carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lai, Zi-Lun& Tsou, Yung-An& Fan, Shin-Ru& Tsai, Ming-Hsui& Chen, Hsiao-Ling& Chang, Nai-Wen…[et al.]. 2014. Methylation-Associated Gene Silencing of RARB in Areca Carcinogens Induced Mouse Oral Squamous Cell Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-467309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lai, Zi-Lun…[et al.]. Methylation-Associated Gene Silencing of RARB in Areca Carcinogens Induced Mouse Oral Squamous Cell Carcinoma. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-467309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lai, Zi-Lun& Tsou, Yung-An& Fan, Shin-Ru& Tsai, Ming-Hsui& Chen, Hsiao-Ling& Chang, Nai-Wen…[et al.]. Methylation-Associated Gene Silencing of RARB in Areca Carcinogens Induced Mouse Oral Squamous Cell Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-467309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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