A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma
المؤلفون المشاركون
Moncada, Benjamin
Torres-Álvarez, Bertha
Castanedo-Cázares, Juan Pablo
Fuentes-Ahumada, Cornelia
Martínez-Ramírez, Juan David
Navarrete-Solís, Josefina
Oros-Ovalle, Cuauhtemoc
González, Francisco Javier
المصدر
Dermatology Research and Practice
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Multiple modalities have been used in the treatment of melasma with variable success.
Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes.
Objective.
To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients.
Patients and Methods.
Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other.
Sunscreen was applied along the observation period.
They were assessed by noninvasive techniques for the evaluation of skin color, as well as subjective scales and histological sections initially and after the treatment with niacinamide.
Results.
All patients showed pigment improvement with both treatments.
Colorimetric measures did not show statistical differences between both sides.
However, good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ.
Niacinamide reduced importantly the mast cell infiltrate and showed improvement of solar elastosis in melasma skin.
Side effects were present in 18% with niacinamide versus 29% with HQ.
Conclusion.
Niacinamide induces a decrease in pigmentation, inflammatory infiltrate, and solar elastosis.
Niacinamide is a safe and effective therapeutic agent for this condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Navarrete-Solís, Josefina& Castanedo-Cázares, Juan Pablo& Torres-Álvarez, Bertha& Oros-Ovalle, Cuauhtemoc& Fuentes-Ahumada, Cornelia& González, Francisco Javier…[et al.]. 2011. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Navarrete-Solís, Josefina…[et al.]. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-467381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Navarrete-Solís, Josefina& Castanedo-Cázares, Juan Pablo& Torres-Álvarez, Bertha& Oros-Ovalle, Cuauhtemoc& Fuentes-Ahumada, Cornelia& González, Francisco Javier…[et al.]. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر