A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma
Joint Authors
Moncada, Benjamin
Torres-Álvarez, Bertha
Castanedo-Cázares, Juan Pablo
Fuentes-Ahumada, Cornelia
Martínez-Ramírez, Juan David
Navarrete-Solís, Josefina
Oros-Ovalle, Cuauhtemoc
González, Francisco Javier
Source
Dermatology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Multiple modalities have been used in the treatment of melasma with variable success.
Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes.
Objective.
To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients.
Patients and Methods.
Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other.
Sunscreen was applied along the observation period.
They were assessed by noninvasive techniques for the evaluation of skin color, as well as subjective scales and histological sections initially and after the treatment with niacinamide.
Results.
All patients showed pigment improvement with both treatments.
Colorimetric measures did not show statistical differences between both sides.
However, good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ.
Niacinamide reduced importantly the mast cell infiltrate and showed improvement of solar elastosis in melasma skin.
Side effects were present in 18% with niacinamide versus 29% with HQ.
Conclusion.
Niacinamide induces a decrease in pigmentation, inflammatory infiltrate, and solar elastosis.
Niacinamide is a safe and effective therapeutic agent for this condition.
American Psychological Association (APA)
Navarrete-Solís, Josefina& Castanedo-Cázares, Juan Pablo& Torres-Álvarez, Bertha& Oros-Ovalle, Cuauhtemoc& Fuentes-Ahumada, Cornelia& González, Francisco Javier…[et al.]. 2011. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467381
Modern Language Association (MLA)
Navarrete-Solís, Josefina…[et al.]. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-467381
American Medical Association (AMA)
Navarrete-Solís, Josefina& Castanedo-Cázares, Juan Pablo& Torres-Álvarez, Bertha& Oros-Ovalle, Cuauhtemoc& Fuentes-Ahumada, Cornelia& González, Francisco Javier…[et al.]. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-467381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467381