Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects
المؤلفون المشاركون
Godar, Sean C.
Bortolato, Marco
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Converging lines of clinical and epidemiological evidence suggest that viral infections in early developmental stages may be a causal factor in neuropsychiatric disorders such as schizophrenia, bipolar disorder, and autism-spectrum disorders.
This etiological link, however, remains controversial in view of the lack of consistent and reproducible associations between viruses and mental illness.
Animal models of virus-induced neurobehavioral disturbances afford powerful tools to test etiological hypotheses and explore pathophysiological mechanisms.
Prenatal or neonatal inoculations of neurotropic agents (such as herpes-, influenza-, and retroviruses) in rodents result in a broad spectrum of long-term alterations reminiscent of psychiatric abnormalities.
Nevertheless, the complexity of these sequelae often poses methodological and interpretational challenges and thwarts their characterization.
The recent conceptual advancements in psychiatric nosology and behavioral science may help determine new heuristic criteria to enhance the translational value of these models.
A particularly critical issue is the identification of intermediate phenotypes, defined as quantifiable factors representing single neurochemical, neuropsychological, or neuroanatomical aspects of a diagnostic category.
In this paper, we examine how the employment of these novel concepts may lead to new methodological refinements in the study of virus-induced neurobehavioral sequelae through animal models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bortolato, Marco& Godar, Sean C.. 2010. Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-467485
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bortolato, Marco& Godar, Sean C.. Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects. Interdisciplinary Perspectives on Infectious Diseases No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-467485
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bortolato, Marco& Godar, Sean C.. Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects. Interdisciplinary Perspectives on Infectious Diseases. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-467485
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467485
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر