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Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects
Joint Authors
Godar, Sean C.
Bortolato, Marco
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Converging lines of clinical and epidemiological evidence suggest that viral infections in early developmental stages may be a causal factor in neuropsychiatric disorders such as schizophrenia, bipolar disorder, and autism-spectrum disorders.
This etiological link, however, remains controversial in view of the lack of consistent and reproducible associations between viruses and mental illness.
Animal models of virus-induced neurobehavioral disturbances afford powerful tools to test etiological hypotheses and explore pathophysiological mechanisms.
Prenatal or neonatal inoculations of neurotropic agents (such as herpes-, influenza-, and retroviruses) in rodents result in a broad spectrum of long-term alterations reminiscent of psychiatric abnormalities.
Nevertheless, the complexity of these sequelae often poses methodological and interpretational challenges and thwarts their characterization.
The recent conceptual advancements in psychiatric nosology and behavioral science may help determine new heuristic criteria to enhance the translational value of these models.
A particularly critical issue is the identification of intermediate phenotypes, defined as quantifiable factors representing single neurochemical, neuropsychological, or neuroanatomical aspects of a diagnostic category.
In this paper, we examine how the employment of these novel concepts may lead to new methodological refinements in the study of virus-induced neurobehavioral sequelae through animal models.
American Psychological Association (APA)
Bortolato, Marco& Godar, Sean C.. 2010. Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-467485
Modern Language Association (MLA)
Bortolato, Marco& Godar, Sean C.. Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects. Interdisciplinary Perspectives on Infectious Diseases No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-467485
American Medical Association (AMA)
Bortolato, Marco& Godar, Sean C.. Animal Models of Virus-Induced Neurobehavioral Sequelae : Recent Advances, Methodological Issues, and Future Prospects. Interdisciplinary Perspectives on Infectious Diseases. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-467485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467485