Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors : A Pharmacological Perspective
المؤلفون المشاركون
Brown, Dominique Xavier
Evans, Marc
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In recent years the incretin therapies have provided a new treatment option for patients with type 2 diabetes mellitus (T2DM).
The incretin therapies focus on the increasing levels of the two incretin hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
This results in increased glucose dependent insulin synthesis and release.
GLP-1 receptor agonists such as liraglutide and exenatide exert an intrinsic biological effect on GLP-1 receptors directly stimulating the release of insulin from pancreatic beta cells.
DPP-4 inhibitors such as sitagliptin and linagliptin prevent the inactivation of endogenous GLP-1 and GIP through competitive inhibition of the DPP-4 enzyme.
Both incretin therapies have good safety and tolerability profiles and interact minimally with a number of medications commonly prescribed in T2DM.
This paper focuses on the pharmacological basis by which the incretin therapies function and how this knowledge can inform and benefit clinical decisions.
Each individual incretin agent has benefits and pitfalls relating to aspects such as glycaemic and nonglycaemic efficacy, safety and tolerability, ease of administration, and cost.
Overall, a personalized medicine approach has been found to be favourable, tailoring the incretin agent to benefit and suit patient's needs such as renal impairment (RI) or hepatic impairment (HI).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brown, Dominique Xavier& Evans, Marc. 2012. Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors : A Pharmacological Perspective. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467599
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brown, Dominique Xavier& Evans, Marc. Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors : A Pharmacological Perspective. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467599
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brown, Dominique Xavier& Evans, Marc. Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors : A Pharmacological Perspective. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467599
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467599
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر