The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?
المؤلفون المشاركون
Zhuravin, I. A.
Turner, Anthony J.
Belyaev, N. D.
Nalivaeva, N. N.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The amyloid cascade hypothesis of Alzheimer's disease (AD) postulates that accumulation in the brain of amyloid β-peptide (Aβ) is the primary trigger for neuronal loss specific to this pathology.
In healthy brain, Aβ levels are regulated by a dynamic equilibrium between Aβ release from the amyloid precursor protein (APP) and its removal by perivascular drainage or by amyloid-degrading enzymes (ADEs).
During the last decade, the ADE family was fast growing, and currently it embraces more than 20 members.
There are solid data supporting involvement of each of them in Aβ clearance but a zinc metallopeptidase neprilysin (NEP) is considered as a major ADE.
NEP plays an important role in brain function due to its role in terminating neuropeptide signalling and its decrease during ageing or after such pathologies as hypoxia or ischemia contribute significantly to the development of AD pathology.
The recently discovered mechanism of epigenetic regulation of NEP by the APP intracellular domain (AICD) opens new avenues for its therapeutic manipulation and raises hope for developing preventive strategies in AD.
However, consideration needs to be given to the diverse physiological roles of NEP.
This paper critically evaluates general biochemical and physiological functions of NEP and their therapeutic relevance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nalivaeva, N. N.& Belyaev, N. D.& Zhuravin, I. A.& Turner, Anthony J.. 2012. The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-467788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nalivaeva, N. N.…[et al.]. The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-467788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nalivaeva, N. N.& Belyaev, N. D.& Zhuravin, I. A.& Turner, Anthony J.. The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-467788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر