The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?
Joint Authors
Zhuravin, I. A.
Turner, Anthony J.
Belyaev, N. D.
Nalivaeva, N. N.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The amyloid cascade hypothesis of Alzheimer's disease (AD) postulates that accumulation in the brain of amyloid β-peptide (Aβ) is the primary trigger for neuronal loss specific to this pathology.
In healthy brain, Aβ levels are regulated by a dynamic equilibrium between Aβ release from the amyloid precursor protein (APP) and its removal by perivascular drainage or by amyloid-degrading enzymes (ADEs).
During the last decade, the ADE family was fast growing, and currently it embraces more than 20 members.
There are solid data supporting involvement of each of them in Aβ clearance but a zinc metallopeptidase neprilysin (NEP) is considered as a major ADE.
NEP plays an important role in brain function due to its role in terminating neuropeptide signalling and its decrease during ageing or after such pathologies as hypoxia or ischemia contribute significantly to the development of AD pathology.
The recently discovered mechanism of epigenetic regulation of NEP by the APP intracellular domain (AICD) opens new avenues for its therapeutic manipulation and raises hope for developing preventive strategies in AD.
However, consideration needs to be given to the diverse physiological roles of NEP.
This paper critically evaluates general biochemical and physiological functions of NEP and their therapeutic relevance.
American Psychological Association (APA)
Nalivaeva, N. N.& Belyaev, N. D.& Zhuravin, I. A.& Turner, Anthony J.. 2012. The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-467788
Modern Language Association (MLA)
Nalivaeva, N. N.…[et al.]. The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-467788
American Medical Association (AMA)
Nalivaeva, N. N.& Belyaev, N. D.& Zhuravin, I. A.& Turner, Anthony J.. The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin : Can We Control It?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-467788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467788