Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma

المؤلفون المشاركون

Kuang, Miao-Huan
Lin, Yue-Hao
Liu, Wan-Li
Liu, Peng
Dai, Shu-Qin
Du, Jun
Wang, Jun-Ye
Zhang, Ge
Zhang, Lin

المصدر

Clinical and Developmental Immunology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-10-13

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأحياء

الملخص EN

The indoleamine 2,3-dioxygenase-(IDO-) mediated microenvironment plays an important role in tumor immune escape.

However, the inhibitory effects of IDO on the CD8+ tumour-infiltrating lymphocytes (CD8+ TILs) in esophageal squamous cell carcinoma (ESCC) have not been clarified yet.

Here, we found that the level of IDO expression in ESCC tumor specimens correlated with a reduction in the number of CD8+ TILs.

Patients with high IDO expression and a low number of CD8+ TILs had significantly impaired overall survival time.

IDO expression and functional enzyme activity in ESCC cell lines could be induced by IFNγ.

When exposed to the milieu generated by IDO-expressing Eca109 cells, the CD8+ TILs were suppressed in proliferation, and their cytolytic functions against target tumor cells were lost.

These results suggested that impairing CD8+ TIL functions by IDO expressed in ESCC possibly contributed to the finding that patients with higher IDO expression have more aggressive disease progression and shorter overall survival time.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Ge& Liu, Wan-Li& Zhang, Lin& Wang, Jun-Ye& Kuang, Miao-Huan& Liu, Peng…[et al.]. 2011. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-467868

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Ge…[et al.]. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clinical and Developmental Immunology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-467868

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Ge& Liu, Wan-Li& Zhang, Lin& Wang, Jun-Ye& Kuang, Miao-Huan& Liu, Peng…[et al.]. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-467868

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-467868