Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma
Joint Authors
Kuang, Miao-Huan
Lin, Yue-Hao
Liu, Wan-Li
Liu, Peng
Dai, Shu-Qin
Du, Jun
Wang, Jun-Ye
Zhang, Ge
Zhang, Lin
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The indoleamine 2,3-dioxygenase-(IDO-) mediated microenvironment plays an important role in tumor immune escape.
However, the inhibitory effects of IDO on the CD8+ tumour-infiltrating lymphocytes (CD8+ TILs) in esophageal squamous cell carcinoma (ESCC) have not been clarified yet.
Here, we found that the level of IDO expression in ESCC tumor specimens correlated with a reduction in the number of CD8+ TILs.
Patients with high IDO expression and a low number of CD8+ TILs had significantly impaired overall survival time.
IDO expression and functional enzyme activity in ESCC cell lines could be induced by IFNγ.
When exposed to the milieu generated by IDO-expressing Eca109 cells, the CD8+ TILs were suppressed in proliferation, and their cytolytic functions against target tumor cells were lost.
These results suggested that impairing CD8+ TIL functions by IDO expressed in ESCC possibly contributed to the finding that patients with higher IDO expression have more aggressive disease progression and shorter overall survival time.
American Psychological Association (APA)
Zhang, Ge& Liu, Wan-Li& Zhang, Lin& Wang, Jun-Ye& Kuang, Miao-Huan& Liu, Peng…[et al.]. 2011. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-467868
Modern Language Association (MLA)
Zhang, Ge…[et al.]. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clinical and Developmental Immunology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-467868
American Medical Association (AMA)
Zhang, Ge& Liu, Wan-Li& Zhang, Lin& Wang, Jun-Ye& Kuang, Miao-Huan& Liu, Peng…[et al.]. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-467868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467868