Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors

المؤلفون المشاركون

Diniz, Gabriela Placoná
Carneiro-Ramos, Marcela Sorelli
Barreto-Chaves, Maria Luiza Morais

المصدر

International Journal of Endocrinology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-06-02

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-β1 (TGF-β1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R).

However, the possible involvement of this factor in TH-induced cardiac hypertrophy is unknown.

In this study we evaluated whether TH is able to modulate TGF-β1 in isolated cardiac, as well as the possible contribution of AT1R and AT2R in this response.

The cardiac fibroblasts treated with T3 did not show alteration on TGF-β1 expression.

However, cardiomyocytes treated with T3 presented an increase in TGF-β1 expression, as well as an increase in protein synthesis.

The AT1R blockade prevented the T3-induced cardiomyocyte hypertrophy, while the AT2R blockage attenuated this response.

The T3-induced increase on TGF-β1 expression in cardiomyocytes was not changed by the use of AT1R and AT2R blockers.

These results indicate that Angiotensin II receptors are not implicated in T3-induced increase on TGF-β expression and suggest that the trophic effects exerted by T3 on cardiomyocytes are not dependent on the higher TGF-β1 levels, since the AT1R and AT2R blockers were able to attenuate the T3-induced cardiomyocyte hypertrophy but were not able to attenuate the increase on TGF-β1 levels promoted by T3.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Diniz, Gabriela Placoná& Carneiro-Ramos, Marcela Sorelli& Barreto-Chaves, Maria Luiza Morais. 2010. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467883

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Diniz, Gabriela Placoná…[et al.]. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-467883

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Diniz, Gabriela Placoná& Carneiro-Ramos, Marcela Sorelli& Barreto-Chaves, Maria Luiza Morais. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467883

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-467883