Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors
Joint Authors
Diniz, Gabriela Placoná
Carneiro-Ramos, Marcela Sorelli
Barreto-Chaves, Maria Luiza Morais
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-β1 (TGF-β1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R).
However, the possible involvement of this factor in TH-induced cardiac hypertrophy is unknown.
In this study we evaluated whether TH is able to modulate TGF-β1 in isolated cardiac, as well as the possible contribution of AT1R and AT2R in this response.
The cardiac fibroblasts treated with T3 did not show alteration on TGF-β1 expression.
However, cardiomyocytes treated with T3 presented an increase in TGF-β1 expression, as well as an increase in protein synthesis.
The AT1R blockade prevented the T3-induced cardiomyocyte hypertrophy, while the AT2R blockage attenuated this response.
The T3-induced increase on TGF-β1 expression in cardiomyocytes was not changed by the use of AT1R and AT2R blockers.
These results indicate that Angiotensin II receptors are not implicated in T3-induced increase on TGF-β expression and suggest that the trophic effects exerted by T3 on cardiomyocytes are not dependent on the higher TGF-β1 levels, since the AT1R and AT2R blockers were able to attenuate the T3-induced cardiomyocyte hypertrophy but were not able to attenuate the increase on TGF-β1 levels promoted by T3.
American Psychological Association (APA)
Diniz, Gabriela Placoná& Carneiro-Ramos, Marcela Sorelli& Barreto-Chaves, Maria Luiza Morais. 2010. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467883
Modern Language Association (MLA)
Diniz, Gabriela Placoná…[et al.]. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-467883
American Medical Association (AMA)
Diniz, Gabriela Placoná& Carneiro-Ramos, Marcela Sorelli& Barreto-Chaves, Maria Luiza Morais. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467883