Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors
المؤلفون المشاركون
Diniz, Gabriela Placoná
Carneiro-Ramos, Marcela Sorelli
Barreto-Chaves, Maria Luiza Morais
المصدر
International Journal of Endocrinology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-β1 (TGF-β1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R).
However, the possible involvement of this factor in TH-induced cardiac hypertrophy is unknown.
In this study we evaluated whether TH is able to modulate TGF-β1 in isolated cardiac, as well as the possible contribution of AT1R and AT2R in this response.
The cardiac fibroblasts treated with T3 did not show alteration on TGF-β1 expression.
However, cardiomyocytes treated with T3 presented an increase in TGF-β1 expression, as well as an increase in protein synthesis.
The AT1R blockade prevented the T3-induced cardiomyocyte hypertrophy, while the AT2R blockage attenuated this response.
The T3-induced increase on TGF-β1 expression in cardiomyocytes was not changed by the use of AT1R and AT2R blockers.
These results indicate that Angiotensin II receptors are not implicated in T3-induced increase on TGF-β expression and suggest that the trophic effects exerted by T3 on cardiomyocytes are not dependent on the higher TGF-β1 levels, since the AT1R and AT2R blockers were able to attenuate the T3-induced cardiomyocyte hypertrophy but were not able to attenuate the increase on TGF-β1 levels promoted by T3.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Diniz, Gabriela Placoná& Carneiro-Ramos, Marcela Sorelli& Barreto-Chaves, Maria Luiza Morais. 2010. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467883
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Diniz, Gabriela Placoná…[et al.]. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-467883
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Diniz, Gabriela Placoná& Carneiro-Ramos, Marcela Sorelli& Barreto-Chaves, Maria Luiza Morais. Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467883
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467883
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر