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Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats
المؤلفون المشاركون
Puchalska, L.
Szczepanska-Sadowska, E.
Borowik, O.
Dobruch, J.
Cudnoch-Jedrzejewska, A.
Pachucki, J.
Czarzasta, K.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Previous studies showed that chronically stressed and myocardially infarcted rats respond with exaggerated cardiovascular responses to acute stress.
The present experiments were designed to elucidate whether this effect can be abolished by treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.
Sprague Dawley rats were subjected either to sham surgery (Groups 1 and 2) or to myocardial infarction (Groups 3 and 4).
The rats of Groups 2 and 4 were also exposed to mild chronic stressing.
Four weeks after the operation, mean arterial blood pressure (MABP) and heart rate (HR) were measured under resting conditions and after application of acute stress.
The cardiovascular responses to the acute stress were determined again 24 h after administration of captopril orally.
Captopril significantly reduced resting MABP in each group.
Before administration of captopril, the maximum increases in MABP evoked by the acute stressor in all (infarcted and sham-operated) chronically stressed rats and also in the infarcted nonchronically stressed rats were significantly greater than in the sham-operated rats not exposed to chronic stressing.
These differences were abolished by captopril.
The results suggest that ACE may improve tolerance of acute stress in heart failure and during chronic stressing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cudnoch-Jedrzejewska, A.& Czarzasta, K.& Puchalska, L.& Dobruch, J.& Borowik, O.& Pachucki, J.…[et al.]. 2014. Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-467902
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cudnoch-Jedrzejewska, A.…[et al.]. Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-467902
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cudnoch-Jedrzejewska, A.& Czarzasta, K.& Puchalska, L.& Dobruch, J.& Borowik, O.& Pachucki, J.…[et al.]. Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-467902
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467902
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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