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Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats
Joint Authors
Puchalska, L.
Szczepanska-Sadowska, E.
Borowik, O.
Dobruch, J.
Cudnoch-Jedrzejewska, A.
Pachucki, J.
Czarzasta, K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Previous studies showed that chronically stressed and myocardially infarcted rats respond with exaggerated cardiovascular responses to acute stress.
The present experiments were designed to elucidate whether this effect can be abolished by treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.
Sprague Dawley rats were subjected either to sham surgery (Groups 1 and 2) or to myocardial infarction (Groups 3 and 4).
The rats of Groups 2 and 4 were also exposed to mild chronic stressing.
Four weeks after the operation, mean arterial blood pressure (MABP) and heart rate (HR) were measured under resting conditions and after application of acute stress.
The cardiovascular responses to the acute stress were determined again 24 h after administration of captopril orally.
Captopril significantly reduced resting MABP in each group.
Before administration of captopril, the maximum increases in MABP evoked by the acute stressor in all (infarcted and sham-operated) chronically stressed rats and also in the infarcted nonchronically stressed rats were significantly greater than in the sham-operated rats not exposed to chronic stressing.
These differences were abolished by captopril.
The results suggest that ACE may improve tolerance of acute stress in heart failure and during chronic stressing.
American Psychological Association (APA)
Cudnoch-Jedrzejewska, A.& Czarzasta, K.& Puchalska, L.& Dobruch, J.& Borowik, O.& Pachucki, J.…[et al.]. 2014. Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-467902
Modern Language Association (MLA)
Cudnoch-Jedrzejewska, A.…[et al.]. Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-467902
American Medical Association (AMA)
Cudnoch-Jedrzejewska, A.& Czarzasta, K.& Puchalska, L.& Dobruch, J.& Borowik, O.& Pachucki, J.…[et al.]. Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-467902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467902