Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition
المؤلفون المشاركون
Ha, Tae Youl
Kim, Heemun
Ahn, Jiyun
Jung, Chang Hwa
Jung, Sung Keun
Um, Min Young
Son, Kun-Ho
Kim, Tae Wan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Anthricin (deoxypodophyllotoxin) is a natural product isolated from Anthriscus sylvestris (L.) Hoffm.
(Apiaceae).
Here, we investigated the effect of anthricin on autophagy and mammalian target of rapamycin (mTOR) signaling as anticancer actions in breast cancer cells.
Many studies have supported the contention that the phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway is considerably deregulated in breast cancer and that autophagy plays important roles in the development of this type of cancer, although the exact underlying mechanisms remain unknown.
Our data confirmed that anthricin markedly induced apoptosis in 2 breast cancer cell lines, MCF7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor, progesterone receptor, and Her2/Neu receptor negative).
Anthricin treatment decreased the levels of phosphorylated Akt and mTORC1, followed by inhibition of cell growth.
Interestingly, blockage of autophagy by a pharmacological inhibitor or genetic deletion of ULK1 and Atg13 accelerated anthricin-induced apoptosis, suggesting that autophagy has cytoprotective effects.
Taken together, our results indicate that anthricin is an inhibitor of mTOR and that a combination of an autophagy inhibitor and anthricin may serve as a new promising strategy for the treatment of breast cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jung, Chang Hwa& Kim, Heemun& Ahn, Jiyun& Jung, Sung Keun& Um, Min Young& Son, Kun-Ho…[et al.]. 2013. Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467914
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jung, Chang Hwa…[et al.]. Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-467914
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jung, Chang Hwa& Kim, Heemun& Ahn, Jiyun& Jung, Sung Keun& Um, Min Young& Son, Kun-Ho…[et al.]. Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467914
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467914
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر