Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition
Joint Authors
Ha, Tae Youl
Kim, Heemun
Ahn, Jiyun
Jung, Chang Hwa
Jung, Sung Keun
Um, Min Young
Son, Kun-Ho
Kim, Tae Wan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Anthricin (deoxypodophyllotoxin) is a natural product isolated from Anthriscus sylvestris (L.) Hoffm.
(Apiaceae).
Here, we investigated the effect of anthricin on autophagy and mammalian target of rapamycin (mTOR) signaling as anticancer actions in breast cancer cells.
Many studies have supported the contention that the phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway is considerably deregulated in breast cancer and that autophagy plays important roles in the development of this type of cancer, although the exact underlying mechanisms remain unknown.
Our data confirmed that anthricin markedly induced apoptosis in 2 breast cancer cell lines, MCF7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor, progesterone receptor, and Her2/Neu receptor negative).
Anthricin treatment decreased the levels of phosphorylated Akt and mTORC1, followed by inhibition of cell growth.
Interestingly, blockage of autophagy by a pharmacological inhibitor or genetic deletion of ULK1 and Atg13 accelerated anthricin-induced apoptosis, suggesting that autophagy has cytoprotective effects.
Taken together, our results indicate that anthricin is an inhibitor of mTOR and that a combination of an autophagy inhibitor and anthricin may serve as a new promising strategy for the treatment of breast cancer cells.
American Psychological Association (APA)
Jung, Chang Hwa& Kim, Heemun& Ahn, Jiyun& Jung, Sung Keun& Um, Min Young& Son, Kun-Ho…[et al.]. 2013. Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467914
Modern Language Association (MLA)
Jung, Chang Hwa…[et al.]. Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-467914
American Medical Association (AMA)
Jung, Chang Hwa& Kim, Heemun& Ahn, Jiyun& Jung, Sung Keun& Um, Min Young& Son, Kun-Ho…[et al.]. Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting AktmTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467914