Functional Expression Study of Igf2 Antisense Transcript in Mouse

المؤلفون المشاركون

Braunschweig, Martin H.
Duart-Garcia, Carolina

المصدر

International Journal of Genomics

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-01-16

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Insulin-like growth factor antisense gene (Igf2as) expression was investigated in different mouse tissues during development, in differentiating C2C12 cells and in a ΔDMR1-U2 knockout mouse model.

The expression levels of Igf2as were high in fetal and newborn liver and muscle tissues compared to adults.

The Igf2as gene was also expressed in placenta and in brain.

The expression data suggests that the Igf2as gene plays a role in early development of the mouse and in placenta.

There was no consistent evidence for an interaction between Igf2 and Igf2as transcripts.

Furthermore, in knockout placentas lacking Igf2as transcription, Igf2 expression was comparable to that in wild type.

These results indicate that Igf2as does not regulate Igf2 sense transcripts.

In previous studies, it was suggested that the ΔDMR1-U2 knockout mouse showing intrauterine growth restriction was caused by the absence of placenta-specific Igf2 P0 transcription.

We conclude that the ΔDMR1-U2 deletion phenotype should be reconsidered in the light of a functional Igf2as gene.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Duart-Garcia, Carolina& Braunschweig, Martin H.. 2014. Functional Expression Study of Igf2 Antisense Transcript in Mouse. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468313

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Duart-Garcia, Carolina& Braunschweig, Martin H.. Functional Expression Study of Igf2 Antisense Transcript in Mouse. International Journal of Genomics No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-468313

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Duart-Garcia, Carolina& Braunschweig, Martin H.. Functional Expression Study of Igf2 Antisense Transcript in Mouse. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468313

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-468313