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Functional Expression Study of Igf2 Antisense Transcript in Mouse
Joint Authors
Braunschweig, Martin H.
Duart-Garcia, Carolina
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Insulin-like growth factor antisense gene (Igf2as) expression was investigated in different mouse tissues during development, in differentiating C2C12 cells and in a ΔDMR1-U2 knockout mouse model.
The expression levels of Igf2as were high in fetal and newborn liver and muscle tissues compared to adults.
The Igf2as gene was also expressed in placenta and in brain.
The expression data suggests that the Igf2as gene plays a role in early development of the mouse and in placenta.
There was no consistent evidence for an interaction between Igf2 and Igf2as transcripts.
Furthermore, in knockout placentas lacking Igf2as transcription, Igf2 expression was comparable to that in wild type.
These results indicate that Igf2as does not regulate Igf2 sense transcripts.
In previous studies, it was suggested that the ΔDMR1-U2 knockout mouse showing intrauterine growth restriction was caused by the absence of placenta-specific Igf2 P0 transcription.
We conclude that the ΔDMR1-U2 deletion phenotype should be reconsidered in the light of a functional Igf2as gene.
American Psychological Association (APA)
Duart-Garcia, Carolina& Braunschweig, Martin H.. 2014. Functional Expression Study of Igf2 Antisense Transcript in Mouse. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468313
Modern Language Association (MLA)
Duart-Garcia, Carolina& Braunschweig, Martin H.. Functional Expression Study of Igf2 Antisense Transcript in Mouse. International Journal of Genomics No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-468313
American Medical Association (AMA)
Duart-Garcia, Carolina& Braunschweig, Martin H.. Functional Expression Study of Igf2 Antisense Transcript in Mouse. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468313