Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment
المؤلفون المشاركون
Sugiura, Saiko
Sone, Michihiko
Ueda, Hiromi
Uchida, Yasue
Nakashima, Tsutomu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Age-related hearing impairment (ARHI) is a complex, multifactorial disorder that is attributable to confounding intrinsic and extrinsic factors.
The degree of impairment shows substantial variation between individuals, as is also observed in the senescence of other functions.
This individual variation would seem to refute the stereotypical view that hearing deterioration with age is inevitable and may indicate that there is ample scope for preventive intervention.
Genetic predisposition could account for a sizable proportion of interindividual variation.
Over the past decade or so, tremendous progress has been made through research into the genetics of various forms of hearing impairment, including ARHI and our knowledge of the complex mechanisms of auditory function has increased substantially.
Here, we give an overview of recent investigations aimed at identifying the genetic risk factors involved in ARHI and of what we currently know about its pathophysiology.
This review is divided into the following sections: (i) genes causing monogenic hearing impairment with phenotypic similarities to ARHI; (ii) genes involved in oxidative stress, biologic stress responses, and mitochondrial dysfunction; and (iii) candidate genes for senescence, other geriatric diseases, and neurodegeneration.
Progress and prospects in genetic research are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uchida, Yasue& Sugiura, Saiko& Sone, Michihiko& Ueda, Hiromi& Nakashima, Tsutomu. 2014. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-468335
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uchida, Yasue…[et al.]. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-468335
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uchida, Yasue& Sugiura, Saiko& Sone, Michihiko& Ueda, Hiromi& Nakashima, Tsutomu. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-468335
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468335
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر