Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment
Joint Authors
Sugiura, Saiko
Sone, Michihiko
Ueda, Hiromi
Uchida, Yasue
Nakashima, Tsutomu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Age-related hearing impairment (ARHI) is a complex, multifactorial disorder that is attributable to confounding intrinsic and extrinsic factors.
The degree of impairment shows substantial variation between individuals, as is also observed in the senescence of other functions.
This individual variation would seem to refute the stereotypical view that hearing deterioration with age is inevitable and may indicate that there is ample scope for preventive intervention.
Genetic predisposition could account for a sizable proportion of interindividual variation.
Over the past decade or so, tremendous progress has been made through research into the genetics of various forms of hearing impairment, including ARHI and our knowledge of the complex mechanisms of auditory function has increased substantially.
Here, we give an overview of recent investigations aimed at identifying the genetic risk factors involved in ARHI and of what we currently know about its pathophysiology.
This review is divided into the following sections: (i) genes causing monogenic hearing impairment with phenotypic similarities to ARHI; (ii) genes involved in oxidative stress, biologic stress responses, and mitochondrial dysfunction; and (iii) candidate genes for senescence, other geriatric diseases, and neurodegeneration.
Progress and prospects in genetic research are discussed.
American Psychological Association (APA)
Uchida, Yasue& Sugiura, Saiko& Sone, Michihiko& Ueda, Hiromi& Nakashima, Tsutomu. 2014. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-468335
Modern Language Association (MLA)
Uchida, Yasue…[et al.]. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-468335
American Medical Association (AMA)
Uchida, Yasue& Sugiura, Saiko& Sone, Michihiko& Ueda, Hiromi& Nakashima, Tsutomu. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-468335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468335