Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication
المؤلفون المشاركون
Benedetto, Pasquale
Socola, Francisco
Loaiza-Bonilla, Arturo
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
We report a case of a Caucasian male with a history of renal cell carcinoma metastatic (mRCC) to the lungs refractory despite aggressive treatment with several lines of targeted therapy.
He was started on axitinib palliative targeted therapy with a good clinical and radiological response; however one month after treatment initiation he presented to the emergency department with severe dyspnea and hypoxemia.
Physical exam and chest X-ray revealed left-sided tension pneumothorax which required emergent thoracostomy with subsequent improvement; however it recurred requiring video assisted thoracoscopy.
A left-sided 4 × 3 cm cavitated necrotic lesion was found at the level of the main pulmonary artery.
Repair with pericardial fat flap was performed.
Surgical biopsies from this lesion revealed mRCC with extensive necrosis.
Imaging studies before and after axitinib use showed an initial 4 × 3 cm mass seen in the same location of this large cavitated necrotic tumor.
Pneumothorax has not been described as a potential major complication from the use of axitinib.
Complete or near-complete responses of mRCC to axitinib targeted therapy may lead to this potential life-threatening complication, particularly if the metastatic lesions are located near to pleural structures.
We also review pertinent clinical trial data on axitinib.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Socola, Francisco& Loaiza-Bonilla, Arturo& Benedetto, Pasquale. 2012. Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-468347
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Socola, Francisco…[et al.]. Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-468347
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Socola, Francisco& Loaiza-Bonilla, Arturo& Benedetto, Pasquale. Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-468347
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468347
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر