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Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication
Joint Authors
Benedetto, Pasquale
Socola, Francisco
Loaiza-Bonilla, Arturo
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report a case of a Caucasian male with a history of renal cell carcinoma metastatic (mRCC) to the lungs refractory despite aggressive treatment with several lines of targeted therapy.
He was started on axitinib palliative targeted therapy with a good clinical and radiological response; however one month after treatment initiation he presented to the emergency department with severe dyspnea and hypoxemia.
Physical exam and chest X-ray revealed left-sided tension pneumothorax which required emergent thoracostomy with subsequent improvement; however it recurred requiring video assisted thoracoscopy.
A left-sided 4 × 3 cm cavitated necrotic lesion was found at the level of the main pulmonary artery.
Repair with pericardial fat flap was performed.
Surgical biopsies from this lesion revealed mRCC with extensive necrosis.
Imaging studies before and after axitinib use showed an initial 4 × 3 cm mass seen in the same location of this large cavitated necrotic tumor.
Pneumothorax has not been described as a potential major complication from the use of axitinib.
Complete or near-complete responses of mRCC to axitinib targeted therapy may lead to this potential life-threatening complication, particularly if the metastatic lesions are located near to pleural structures.
We also review pertinent clinical trial data on axitinib.
American Psychological Association (APA)
Socola, Francisco& Loaiza-Bonilla, Arturo& Benedetto, Pasquale. 2012. Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-468347
Modern Language Association (MLA)
Socola, Francisco…[et al.]. Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-468347
American Medical Association (AMA)
Socola, Francisco& Loaiza-Bonilla, Arturo& Benedetto, Pasquale. Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis : An Unexpected Complication. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-468347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468347