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Persea americana Mill. Seed : Fractionation, Characterization, and Effects on Human Keratinocytes and Fibroblasts
المؤلفون المشاركون
Deters, Alexandra M.
Jerz, Gerold
Villanueva, Socorro
Ramos-Jerz, Maria del R.
Winterhalter, Peter
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Methanolic avocado (Persea americana Mill., Lauraceae) seed extracts were separated by preparative HSCCC.
Partition and HSCCC fractions were principally characterized by LC-ESI-MS/MS analysis.
Their in vitro influence was investigated on proliferation, differentiation, cell viability, and gene expression on HaCaT and normal human epidermal keratinocytes (NHEK) and normal human dermal fibroblasts (NHDF).
The methanol-water partition (M) from avocado seeds and HSCCC fraction 3 (M.3) were mostly composed of chlorogenic acid and its isomers.
Both reduced NHDF but enhanced HaCaT keratinocytes proliferation.
HSCCC fraction M.2 composed of quinic acid among chlorogenic acid and its isomers inhibited proliferation and directly induced differentiation of keratinocytes as observed on gene and protein level.
Furthermore, M.2 increased NHDF proliferation via upregulation of growth factor receptors.
Salidrosides and ABA derivatives present in HSCCC fraction M.6 increased NHDF and keratinocyte proliferation that resulted in differentiation.
The residual solvent fraction M.7 contained among low concentrations of ABA derivatives high amounts of proanthocyanidins B1 and B2 as well as an A-type trimer and stimulated proliferation of normal cells and inhibited the proliferation of immortalized HaCaT keratinocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramos-Jerz, Maria del R.& Villanueva, Socorro& Jerz, Gerold& Winterhalter, Peter& Deters, Alexandra M.. 2013. Persea americana Mill. Seed : Fractionation, Characterization, and Effects on Human Keratinocytes and Fibroblasts. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-468402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramos-Jerz, Maria del R.…[et al.]. Persea americana Mill. Seed : Fractionation, Characterization, and Effects on Human Keratinocytes and Fibroblasts. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-468402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramos-Jerz, Maria del R.& Villanueva, Socorro& Jerz, Gerold& Winterhalter, Peter& Deters, Alexandra M.. Persea americana Mill. Seed : Fractionation, Characterization, and Effects on Human Keratinocytes and Fibroblasts. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-468402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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