The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?
المؤلفون المشاركون
Unsal, Erbil
Akyildiz, Mahir
Makay, Ozer
Icoz, Gokhan
Makay, Balahan
Ozgen, Gokhan
Yetkin, Enis
Yenisey, Cigdem
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-03-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Oxidative stress is regarded as a pathogenic factor in hyperthyroidism.
Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats.
Twenty-one rats were divided into three groups.
Group A served as negative controls.
Group B had untreated thyrotoxicosis, and Group C received melatonin.
Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO•x), and plasma IL-6, IL-10, and TNF-alpha were measured.
MDA, GSH, NO•x, IL-10, and TNF-alpha levels increased after L-thyroxine induction.
An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration.
MDA, GSH, and NO•x levels were also affected by melatonin.
Lowest TNF-alpha levels were observed in Group C.
This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat.
Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Makay, Balahan& Makay, Ozer& Yenisey, Cigdem& Icoz, Gokhan& Ozgen, Gokhan& Unsal, Erbil…[et al.]. 2009. The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-468456
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Makay, Balahan…[et al.]. The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-468456
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Makay, Balahan& Makay, Ozer& Yenisey, Cigdem& Icoz, Gokhan& Ozgen, Gokhan& Unsal, Erbil…[et al.]. The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-468456
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468456
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر