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The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?
Joint Authors
Unsal, Erbil
Akyildiz, Mahir
Makay, Ozer
Icoz, Gokhan
Makay, Balahan
Ozgen, Gokhan
Yetkin, Enis
Yenisey, Cigdem
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxidative stress is regarded as a pathogenic factor in hyperthyroidism.
Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats.
Twenty-one rats were divided into three groups.
Group A served as negative controls.
Group B had untreated thyrotoxicosis, and Group C received melatonin.
Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO•x), and plasma IL-6, IL-10, and TNF-alpha were measured.
MDA, GSH, NO•x, IL-10, and TNF-alpha levels increased after L-thyroxine induction.
An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration.
MDA, GSH, and NO•x levels were also affected by melatonin.
Lowest TNF-alpha levels were observed in Group C.
This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat.
Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response.
American Psychological Association (APA)
Makay, Balahan& Makay, Ozer& Yenisey, Cigdem& Icoz, Gokhan& Ozgen, Gokhan& Unsal, Erbil…[et al.]. 2009. The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-468456
Modern Language Association (MLA)
Makay, Balahan…[et al.]. The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-468456
American Medical Association (AMA)
Makay, Balahan& Makay, Ozer& Yenisey, Cigdem& Icoz, Gokhan& Ozgen, Gokhan& Unsal, Erbil…[et al.]. The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat : Is There a Link?. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-468456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468456