Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection
المؤلفون المشاركون
De Souza, Robson Da Paixão
Almeida, Maria Cecília F.
Alcântara, Leda Maria
Lopes, Giuseppe Tittoni Varela
Cardoso, Luciana Santos
Ilma Araujo, Maria
Carvalho, Edgar M.
Oliveira, Ricardo Riccio
المصدر
Journal of Parasitology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Periportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens.
We evaluated the immune response in S.
mansoni infected individuals with different degrees of periportal fibrosis.
Cytokine and chemokines were measured in serum and in supernatants of PBMC cultures stimulated with the soluble adult worm (SWAP) or egg (SEA) antigens, using a sandwich ELISA.
The levels of IL-5 in response to SEA were higher in individuals with moderate to severe fibrosis (310.9 pg/mL) compared to individuals without fibrosis (36.8 pg/mL; P=0.0418).
There was also a higher production of TNF-α in cultures stimulated with SWAP in patients with insipient fibrosis (1446 pg/mL) compared to those without fibrosis (756.1 pg/mL; P=0.0319).
The serum levels of IL-13 and MIP-1α were higher in subjects without fibrosis than in those with moderate to severe fibrosis.
However a positive association between serum levels of IL-13, TNF-α, MIP-1α, and RANTES and S.
mansoni parasite burden was found.
From these data we conclude that IL-5 and TNF-α may participate in liver pathology in schistosomiasis.
The positive association between IL-13, TNF-α, MIP-1α, and RANTES with parasite burden, however, might predict the development of liver pathology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Souza, Robson Da Paixão& Cardoso, Luciana Santos& Lopes, Giuseppe Tittoni Varela& Almeida, Maria Cecília F.& Oliveira, Ricardo Riccio& Alcântara, Leda Maria…[et al.]. 2012. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Souza, Robson Da Paixão…[et al.]. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-468731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Souza, Robson Da Paixão& Cardoso, Luciana Santos& Lopes, Giuseppe Tittoni Varela& Almeida, Maria Cecília F.& Oliveira, Ricardo Riccio& Alcântara, Leda Maria…[et al.]. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر