Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection
Joint Authors
De Souza, Robson Da Paixão
Almeida, Maria Cecília F.
Alcântara, Leda Maria
Lopes, Giuseppe Tittoni Varela
Cardoso, Luciana Santos
Ilma Araujo, Maria
Carvalho, Edgar M.
Oliveira, Ricardo Riccio
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Periportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens.
We evaluated the immune response in S.
mansoni infected individuals with different degrees of periportal fibrosis.
Cytokine and chemokines were measured in serum and in supernatants of PBMC cultures stimulated with the soluble adult worm (SWAP) or egg (SEA) antigens, using a sandwich ELISA.
The levels of IL-5 in response to SEA were higher in individuals with moderate to severe fibrosis (310.9 pg/mL) compared to individuals without fibrosis (36.8 pg/mL; P=0.0418).
There was also a higher production of TNF-α in cultures stimulated with SWAP in patients with insipient fibrosis (1446 pg/mL) compared to those without fibrosis (756.1 pg/mL; P=0.0319).
The serum levels of IL-13 and MIP-1α were higher in subjects without fibrosis than in those with moderate to severe fibrosis.
However a positive association between serum levels of IL-13, TNF-α, MIP-1α, and RANTES and S.
mansoni parasite burden was found.
From these data we conclude that IL-5 and TNF-α may participate in liver pathology in schistosomiasis.
The positive association between IL-13, TNF-α, MIP-1α, and RANTES with parasite burden, however, might predict the development of liver pathology.
American Psychological Association (APA)
De Souza, Robson Da Paixão& Cardoso, Luciana Santos& Lopes, Giuseppe Tittoni Varela& Almeida, Maria Cecília F.& Oliveira, Ricardo Riccio& Alcântara, Leda Maria…[et al.]. 2012. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468731
Modern Language Association (MLA)
De Souza, Robson Da Paixão…[et al.]. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-468731
American Medical Association (AMA)
De Souza, Robson Da Paixão& Cardoso, Luciana Santos& Lopes, Giuseppe Tittoni Varela& Almeida, Maria Cecília F.& Oliveira, Ricardo Riccio& Alcântara, Leda Maria…[et al.]. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468731