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High Physiological Omega-3 Fatty Acid Supplementation Affects Muscle Fatty Acid Composition and Glucose and Insulin Homeostasis in Obese Adolescents
المؤلفون المشاركون
Dangardt, Frida
Friberg, Peter
Strandvik, Birgitta
Gronowitz, Eva
Dahlgren, Jovanna
Chen, Yun
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Obese adolescents have high concentrations of saturated fatty acids and low omega-3 long-chain polyunsaturated fatty acids (LCUFAs) in plasma phospholipids.
We aimed to investigate effects of omega-3 LCPUFA supplementation to obese adolescents on skeletal muscle lipids and glucose and insulin homeostasis.
Twenty-five obese adolescents (14–17 years old, 14 females) completed a randomized double-blind crossover study supplying capsules containing either 1.2 g omega-3 LCPUFAs or placebo, for 3 months each with a six-week washout period.
Fasting blood glucose, insulin, leptin, adiponectin, and lipids were measured.
Intravenous glucose tolerance test (IVGTT) and euglycemic-hyperinsulinemic clamp were performed, and skeletal muscle biopsies were obtained at the end of each period.
The concentrations of EPA, DHA, and total omega-3 PUFA in muscle phospholipids increased in both sexes.
In the females, omega-3 LCPUFA supplementation improved glucose tolerance by 39% (P=0.04) and restored insulin concentration by 34% (P=0.02) during IVGTT.
Insulin sensitivity improved 17% (P=0.07).
In males, none of these parameters was influenced by omega-3 supplementation.
Thus, three months of supplementation of omega-3 LCPUFA improved glucose and insulin homeostasis in obese girls without influencing body weight.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dangardt, Frida& Chen, Yun& Gronowitz, Eva& Dahlgren, Jovanna& Friberg, Peter& Strandvik, Birgitta. 2012. High Physiological Omega-3 Fatty Acid Supplementation Affects Muscle Fatty Acid Composition and Glucose and Insulin Homeostasis in Obese Adolescents. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-468784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dangardt, Frida…[et al.]. High Physiological Omega-3 Fatty Acid Supplementation Affects Muscle Fatty Acid Composition and Glucose and Insulin Homeostasis in Obese Adolescents. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-468784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dangardt, Frida& Chen, Yun& Gronowitz, Eva& Dahlgren, Jovanna& Friberg, Peter& Strandvik, Birgitta. High Physiological Omega-3 Fatty Acid Supplementation Affects Muscle Fatty Acid Composition and Glucose and Insulin Homeostasis in Obese Adolescents. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-468784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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